Study

Population

Dosage

Side Effects (including percentage experiencing a given side effect)

Boudrez et al. [56]

Non-psychiatric

Not specified

Nausea (8.9%), insomnia (2.9%), and sleep disorder (2.2%)

Gonzales et al. [57]

Non-psychiatric

1 mg BID

Nausea (28%), insomnia (14%), dry mouth (6.7%), headache (15.5%), and dizziness (6%)

Jorenby et al. [59]

Non-psychiatric

1 mg BID

Nausea (29.4%), insomnia (14.2%), abnormal dreams (13.1%), headache (12.8%), and dry mouth (5.5%)

Nides et al. [61]

Non-psychiatric

1 mg BID

Nausea (52%), insomnia (35.2%), headache (24%), abnormal dreams (15.2%), and taste perversion (15.2%)

Garza et al. [85]

Non-psychiatric

1 mg BID

Nausea (37.7%), insomnia (30.9%), somnolence (20%), and abnormal dreams (9.1%)

Evins and Goff, [88]

Schizophrenia

1 mg BID

Nausea and vomiting (21.1%)

Stapleton et al. [89]

Mentally Ill

Not specified

Nausea (32.1%), and sleep disturbances (32.1%)

Smith et al. [90]

Schizophrenia, schizoaffective

1 mg BID

Mild nausea, shaking, dry mouth, and tiredness-sleepiness (57% of all patients experienced at least one side effect)

Weiner et al. [91]

Schizophrenia

1 mg BID

Constipation (50%), insomnia (75%), and nausea (75%)

Liu et al. [92]

Schizophrenia

1 mg BID

Nausea (10%), vomiting (10%), fatigue (5%), dry mouth (5%), muscle stiffness (5%), and headache (5%)

McClure et al. [97]

Depression

1 mg BID

Tension (51%), nausea (61.6%), sleep disturbance (46.4%), irritability (47.1%), confusion (19.3%), and difficulty concentrating (33.4%)

Philip et al. [98]

Depression

1 mg BID

GI problem (21.4%), sleep disturbances, and irritability (7.1%)

Tonstad et al. [99]

Non-psychiatric

1 mg BID

Sleep disturbance (19.9%)

Table 1: Commonly reported physical side effects of varenicline.