Supplementation (n=7) Placebo (n=6) Comparisonaa)
Variables: mean (SD) 4 week 8 week 12 week 16 week 4 week 8 week 12 week 16 week F P
ADI-R repetitive behavior domains                    
Encopassin b)

preoccupatuion
3.1 (1.5) 3.4 (0.8) 3.0 (1.5) 2.6 (1.5) 2.8 (1.6) 2.0 (1.8) 2.3 (1.6) 2.0 (1.8) 1.46 0.25
Compulsive

adherencebc)
1.4 (1.5) 0.7 (0.8) 2.9 (1.6) 0.0 (0.0) 0.5 (1.2) 0.3 (0.8) 1.8 (1.8) 0.0 (0.0) 0.59 0.62
Stereotyped and  repetitive

motor mannerismsd)
0.0 (0.0) 0.0 (0.0) 0.0 (0.0) 0.0 (0.0) 0.8 (1.6) 0.3 (0.8) 0.2 (0.4) 0.0 (0.0) 3.18 0.04*
Preoccupation with 

parts  of objectse)
2.3 (1.5) 2.3 (1.1) 2.1 (1.3) 1.7 (1.4) 2.0 (1.3) 1.8 (1.2) 2.1 (1.3) 1.5 (1.2) 1.15 0.35
ABC                    
Irritability 13.0 (11.6) 10.6 (10.4) 14.4 (14.3) 8.9 (9.9) 8.2 (7.7) 8.3 (6.3) 8.0 (7.1 9.2 (8.8) 1.78 0.17
Social withdrawal 22.1 (4.6) 13.3 (3.8) 14.4 (8.8) 10.9 (5.1) 18.0 (2.8) 18.2 (7.1) 15.0 (5.1) 17.7 (4.3) 3.08 0.04*
Stereotypy 5.1 (4.5) 2.4 (2.9) 4.4 (7.5) 3.4 ( 4.9) 3.8 (4.5) 2.7 (3.8) 4.0 (4.3) 5.2 (5.7) 0.66 0.58
Hyperactivity 15.0 (9.6) 9.0 (8.4) 14.6 (12.6) 12.0 (10.7) 14.2 (14.1) 12.0 (9.4) 15.7 (7.6) 15.3 (8.1) 0.65 0.59
Inappropriate speech 3.7 (3.6) 3.0 (3.1) 4.4 (4.9) 3.7 (3.9) 3.8 (2.1) 3.8 (2.1) 4.0 (2.8) 5.3 (4.1) 0.79 0.51
Treatment group received supplementation with arachidonic acid (ARA) and docosahexaenoic acid (DHA) for 16 weeks.
ADI-R, Autism Diagnostic Interview- Revised; ABC, Aberrant Behavior Checklist.
1) Repeated measures analysis of variance (ANOVA) was used when baseline scores as a covariate with treatment as the between-subject-factor and test session repeated
factor, * P<0.05.
2) ADI-R algorithm item C 1: Encompassing preoccupation or circumscribed pattern of interest.
3) ADI-R algorithm item C 2: Apparently compulsive adherence to nonfunctional routines or rituals.
4) ADI-R algorithm item C 3: Stereotyped and repetitive motor mannerisms.
5) ADI-R algorithm item C 4: Preoccupation with parts of objects or nonfunctional elements of materials.
Table 2: Mean scores on the Aberrant Behavior Checklist (ABC) and the Social Responsiveness Scale (SRS) for a 16-week randomized double-blind placebo-controlled trial.