Figure 1: Depicts locomotor activity (indicated by ambulations / 10 min as recorded by the Comprehensive Lab Animal Monitoring System) of mice (n = 8 / group) administered intraperitoneal (i.p.) saline or (A) the kappa opioid receptor agonist, U50,488 (0.3, 1.0, or 10.0 mg / kg) or (B) the peripherally-restricted kappa opioid receptor agonist, ffir-NH2 (3 nmol, i.c.v., 10 nmol, i.c.v., 1 mg / kg, i.p., or 10 mg / kg, i.p.). *denotes an interaction wherein the indicated group significantly differs from the respective saline-administered control group (p < 0.05).
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