Experiment 2 Constant Object Novel Object Saline (i.c.v.) / Saline (i.p.) 11 ± 2 18 ± 3 Saline (i.c.v.) / U50,488 (0.3 mg/kg, i.p.) 16 ± 3 14 ± 2 NXM (30 nmol, i.c.v.) / Saline (i.p.) 8 ± 1† 16 ± 2 NXM (30 nmol, i.c.v.) / U50,488 (0.3 mg/kg, i.p.) 7 ± 1† 16 ± 3   Experiment 3 Constant Object Novel Object Saline (i.c.v.) / Saline (i.p.) 10 ± 2 22 ± 3 Saline (i.c.v.) / ffir-NH2 (1 mg/kg, i.p.) 12 + 3 22 ± 4 ffir-NH2 (3 nmol, i.c.v.) / Saline (i.p.) 8 ± 1 6 ± 1‡ ffir-NH2 (3 nmol, i.c.v.) / nor-BNI* (5 mg/kg, i.p.) 11 ± 2 19 ± 3 *nor-BNI = nor-binaltorphimine

Table 1: Presents the amount of time (sec ± SEM) that mice (n = 12 / group) spent investigating the constant and novel objects in the novel object recognition task. † indicates a main effect wherein naloxone methiodide (NXM)-infused mice significantly differed from saline-infused mice on exploration of the constant object, irrespective of peripheral injection condition (p < 0.05). ‡ indicates a significant interaction wherein mice infused with ffir-NH2 significantly differed from salineinfused controls on exploration of the novel, but not constant, object (p < 0.05).

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