Figure 1: Diagram of how CART (A) and orexin (B) -containing cells within the lateral hypothalamus may influence structures involved in the reinstatement of drug-seeking behaviour. The classical ‘final common pathway’ is highlighted in red. Solid lines denote established projections based on functional studies, whilst dotted lines represent projections that are yet to be confirmed. LH: Lateral hypothalamus. NAC: Nucleus accumbens. PFC: Prefrontal cortex. PVT: Paraventricular thalamus. VP: Ventral pallidum. VTA: Ventral tegmental area.