Figure 2: Sex differences and effects of nicotine withdrawal on open field locomotor activity. After acquisition of their baseline open field activity (PD29), mice were injected with 0.3 or 0.6 mg/kg nicotine from PD 30 to PD 44, and re-tested in the open field A, B: Distance traveled in the open field, 1 day before (PD29) and 1 day after (PD45) nicotine treatment, in females (A) and males (B). C, D: Distance traveled in the open field, 1 day before (PD29) and 30 days after (PD74) nicotine treatment in females (C) and males (D).
Abbreviations: F: Females; M: Males; SAL: Saline; 0.3 NIC: 0.3 mg/kg nicotine; 0.6 NIC: 0.6 mg/kg nicotine
~ compared to PD29
#compared to females
*compared to saline, p<0.05