BICOMBO STEAL
ABC/3TC TDF/FTC ABC/3TC TDF/FTC
  n=167 n=166 n=178 n=179
Lost to follow up (%) 13 7.8 27 16.3 4 2.2 2 1.1
Baseline ABC (%) 12 7.2 18 10.8 36 20.2 37 20.7
Baseline TDF (%) 44 26.3 56 33.7 54 30.3 53 29.6
Baseline PI (%) 17 10.2 16 9.6 42 23.6 41 22.9
NRTI exposure [years(sd)] 4.4 2.9 4.1 2.9 5.7 3.4 5.9 3.8
Male (%) 130 77.8 127 76.5 176 98.9 173 96.6
Male homosexual transmission (%)* 55 35.0 51 32.1 157 88.2 159 88.8
Prior AIDS (%) 63 37.7 65 39.2 31 17.4 28 15.6
Age [years(sd) 43 9 45 10 46 9 44 8
CD4 count [cells/mm3(sd)] 533 292 554 299 627 306 599 257
Creatinine clearance [ml/min(sd)] 105 25.2 100 27 112 26.3 114 27.4
eGFR [ml/min/1.73m2 (sd)] 75.7 31.6 73.3 34 98.2 22.4 98.4 17
Triglycerided[mmol/L(sd)] 1.8 1.1 2 1.4 2.2 2.7 2.3 3
Total:HDL ratio 4 1.3 4.2 1.4 4.3 1.6 4.4 1.4
Total cholesterol[mmol/L(sd)] 5.2 1 5.4 1 5.2 1 5.4 1.3
HDL cholesterol[mmol/L(sd)] 1.4 0.4 1.4 0.5 1.3 0.4 1.3 0.4
LDL cholesterol[mmol/L(sd)] 3.1 0.8 3.1 0.9 3.1 0.9 3.1 0.9
ALT > ULN** 48 31.4 54 34.8 40 22.4 36 20.2
AST >ULN† 23 15.6 36 24.8 36 20.1 31 17.4
*Transmisssion information was available only for 157 and 159 participants in ABC/3TC and TDF/FTC BICOMBO arms respectively
**ALT data available only for 153, 155, 178,178 participants on ABC/3TC and TDF/FTC in BICOMBO and STEAL respectively
†AST data available only for 147 and 145 participants on ABC/3TC and TDF/FTC in BICOMBO
ALT-alanine aminotransferase
AST-aspartate aminotransferase
ULN- upper limit of normal
Table I: Baseline characteristics by trial and randomised arm.