| |
BICOMBO |
STEAL |
| |
ABC/3TC |
TDF/FTC |
ABC/3TC |
TDF/FTC |
| |
n=167 |
n=166 |
n=178 |
n=179 |
| |
n |
% |
n |
% |
n |
% |
n |
% |
| Deaths |
0 |
- |
2 |
1.2 |
2 |
1.1 |
2 |
1.1 |
| AIDS events |
1 |
0.6 |
0 |
- |
0 |
- |
0 |
- |
| Serious non-AIDS |
|
|
|
|
|
|
|
|
| Cardio vascular |
2 |
1.2 |
1 |
0.6 |
8 |
4.5 |
1 |
0.6 |
| Study RD [%(95% CI] |
0.6 (-1.4,2.6) |
3.9 (0.7, 7.1) |
| RD[% (95%CI)] |
2.1 (-1.6, 5.7)p=0.267, heterogeneity I272.9 p=0.055 |
| Cancer |
6 |
3.6 |
4 |
2.4 |
5 |
2.8 |
2 |
1.1 |
| Study RD [%(95% CI] |
1.2(-2.5, 4.8) |
1.7 (-1.2, 4.5) |
| RD[% (95%CI)] |
1.5 (-0.8, 3.7) p=0.197, heterogeneity I20.0% p=0.834 |
| Fracture |
3 |
1.8 |
2 |
1.2 |
0 |
0.0 |
1 |
0.6 |
| Renal disease |
0 |
0.0 |
1 |
0.6 |
0 |
0.0 |
0 |
0.0 |
| Liver disease |
0 |
0.0 |
0 |
0.0 |
1 |
0.6 |
0 |
0.0 |
| Total |
11 |
6.6 |
8 |
4.8 |
14 |
7.9 |
4 |
2.2 |
| Study RD [% (95%CI)] |
1.8 |
(-3.2, 6.7) |
|
5.6 |
(1.1, 10.1) |
|
| RD[% (95%CI)] |
3.8 (0.1, 7.6) p=0.044, heterogeneity I2=19.5% p=0.265 |
|
