CLI vs Subgroup (n) Odds ratios (OR) (95% Confidence intervals)
Unadjusted p value  Adjusted* p value
Smoking HIV- (192) 10.70 (7.16-15.83) <0.0001 10.12 (6.01-17.08) <0.0001
  HIV-<60 yrs (64) 10.90 (6.09-19.52) <0.0001 7.75 (4.12-14.55) <0.0001
  HIV-≥60 yrs (128) 10.52 (6.72-16.49) <0.0001 12.84 (6.74-24.47) <0.0001
Hypertension HIV- (192) 2.60 (1.82-3.72) <0.0001 0.76 (0.47-1.21) =0.50
  HIV-<60 yrs (64) 1.93 (1.13-3.31) <0.05 1.15 (0.62-2.13) =0.06
  HIV-≥60 yrs (128) 3.05 (1.99-4.69) <0.0001 0.44 (0.25-0.79) <0.05
  HIV+ (25) 0.24 (0.08-0.70) † <0.0001 0.12 (0.04-0.40) † <0.01
DM HIV- (192) 9.82 (6.36-15.16)    <0.0001 6.71 (4.0-11.3)   <0.0001
  HIV-<60 yrs (64) 12.89 (7.12-23.53) <0.0001  15.06 (7.41-30.60) <0.0001
  HIV-≥60 yrs (128) 8.57 (5.31-13.84) <0.0001 3.93 (2.10-7.14) <0.0001
  HIV+ (25) 0.87 (0.20-3.84) † =0.86 0.95 (0.20-4.54 =0.60
Increased TG HIV- (192) 1.56 (1.03-2.37)    <0.05  0.88 (0.54-1.43)  =0.59
  HIV-<60 yrs (64) 2.47 (1.38-4.43)    <0.005  1.91 (1.02-3.58) <0.05
  HIV-≥60 yrs (128) 1.19 (0.72-1.98)    =0.49 0.47 (0.26-0.86) <0.05
  HIV+ (25) 0.69 (0.20-2.37)   =0.55  0.53 (0.15-1.92)   =0.28
Decreased HDL cholest HIV- (192) 3.17 (2.18-4.59)    <0.0001 3.73 (2.34-5.95)  <0.0001
  HIV-<60 yrs (64) 4.37 (2.50-7.63) < 0.0001 5.81 (3.11-10.86) <0.0001
  HIV-≥60 yrs (128) 2.69 (1.76-4.13)   <0.0001  2.66 (1.54-4.60) =0.001
  HIV+ (25) 2.75 (1.17-6.47) <0.05 3.76 (1.51-9.36) <0.01
DM- Diabetes Mellitus; TG- Tryglycerides; HDL cholest- High Density Lipoprotein Fraction of Cholesterol. *Age and sex-adjusted. Probability values were further adjusted for non-independence of family members. Increased TG indicates values ≥ 1.7 mmol/l. Decreased HDL cholesterol indicates values <1.0 mmol/l for males and <1.2 mmol/l for females. †p<0.001 vs OR for HIV- group.
Table 3: Conventional cardiovascular risk factors associated with Critical Limb Ischemia (CLI) in patients with (+) (n=25) or without (-) (n=192) a Human Immunodeficiency Virus (HIV) infection as compared to a community sample (n=430).