|
Variable |
(1)
Control
(n=14) |
(2)
HIV-infected
OLD-negative
HAART-naive
(n=13) |
(3)
HIV-infected
OLD-negative
HAART-treated
(n=23) |
p-value |
post-hoc p-value |
Difference |
95% CI |
| Viral load assays, n (%) |
N/A |
5(39%) |
23(100%) |
<0.0011 |
|
|
|
| Detectable viral loada, n(%) |
N/A |
5(100%) |
14(61%) |
0.141 |
|
|
|
| Viral load [x103 RNA copies/mL],
geometric mean (95% CI, range) |
N/A |
13.65(0.43 to 436.13, 0.84-935) |
0.53(0.11 to 2.47, 0-625) |
0.0472 |
|
0.04 |
(0.002 to 0.95) |
| |
|
|
|
|
|
|
|
| Exhaled breath H2O2 [µmol/L],
geometric mean (95% CI, range) |
0.21 (0.15 to 0.31, 0.05-0.63) |
0.77 (0.54 to 1.10, 0.42-2.20) |
0.81 (0.66 to 1.00, 0.30-1.80) |
<0.0013 |
<0.0014 1 vs. 2
<0.0014 1 vs. 3
1.004 2 vs. 3 |
3.64
3.83 |
(2.18 to 6.07)
(2.44 to 6.01) |
| Resting CL [mV/104 cells],
geometric mean (95% CI, range) |
0.59 (0.50 to 0.70, 0.28-0.84) |
0.79 (0.66 to 0.94, 0.47-1.22) |
0.87 (0.73 to 1.04, 0.43-2.14) |
0.0043 |
0.0704 1 vs. 2
0.0044 1 vs. 3
1.004 2 vs. 3 |
1.51 |
(1.14 to 2.01) |
| fMLP-induced peak CL [mV/104 cells],
geometric mean (95% CI, range) |
0.92 (0.74 to 1.13, 0.42-2.24) |
1.61 (1.29 to 2.02, 0.90-2.97) |
1.42 (1.19 to 1.70, 0.62-2.87) |
<0.0013 |
0.0014 1 vs. 2
0.0054 1 vs. 3
1.004 2 vs. 3 |
1.76
1.55 |
(1.23 to 2.52)
(1.13 to 2.13) |
| Adjusted variables for significant difference on PMNs count: |
| Exhaled breath H2O2 [µmol/L]
geometric mean (95% CI) |
N/A |
N/A |
N/A |
N/A5 |
|
|
|
| Resting CL [mV/104 cells],
geometric mean (95% CI) |
0.75(0.68 to 0.83) |
0.73(0.67 to 0.80) |
0.77(0.72 to 0.83) |
0.636 |
|
|
|
| fMLP-induced peak CL [mV/104 cells],
geometric mean (95% CI) |
1.13(0.95 to 1.35) |
1.52(1.28 to 1.79) |
1.30(1.14 to 1.47) |
0.0786 |
|
|
|
p-values: 