Variable Sub-Cohort Mean ± SD (n = 58) Parameter Estimate Standard Error T-value P-value
HIV viral load (copies/mL)A 7,856 ± 27,585 -0.789 0.342 -2.31 0.027*
CD4 cell count (cells/uL)A 483 ± 279 36.195 97.733 0.37 0.713
Oxidized glutathione (%) 25.77 ± 9.96 10.625 4.292 2.48 0.029*
MDA (uM) 0.55 ± 0.23 0.098 0.095 1.04 0.311
Mitochondrial 8-oxo-dG (ΔCt) 0.57 ± 0.48 0.009 0.181 0.05 0.961
Complex I enzyme activity (%) 43.84 ± 20.11 -16.909 7.624 -2.22 0.042*
Complex IV enzyme activity (%) 22.09 ± 16.44 1.798 10.238 0.18 0.863
Apoptosis (CK18 Average value (pM)) 126.91 ± 61.15 -5.070 25.903 -0.20 0.847
*Indicates statistically significant results. P-value associated with linear regression analysis. Participants with BMI>28 kg/m2 excluded from regression analysis unless otherwise specified
A No exclusion of participants with BMI>28 in this analysis
Table 5: Effects of theFunctional (Non-Null) GSTM1 Genotype on HIV Disease Progression and Oxidative Stress in Alcohol-Drinking Sub-Cohort.