Effects of theFunctional (Non-Null) GSTM1 Genotype

Variable	Sub-Cohort Mean ± SD (n = 58)	Parameter Estimate	Standard Error	T-value	P-value
HIV viral load (copies/mL)^A	7,856 ± 27,585	-0.789	0.342	-2.31	0.027*
CD4 cell count (cells/uL)^A	483 ± 279	36.195	97.733	0.37	0.713
Oxidized glutathione (%)	25.77 ± 9.96	10.625	4.292	2.48	0.029*
MDA (uM)	0.55 ± 0.23	0.098	0.095	1.04	0.311
Mitochondrial 8-oxo-dG (ΔCt)	0.57 ± 0.48	0.009	0.181	0.05	0.961
Complex I enzyme activity (%)	43.84 ± 20.11	-16.909	7.624	-2.22	0.042*
Complex IV enzyme activity (%)	22.09 ± 16.44	1.798	10.238	0.18	0.863
Apoptosis (CK18 Average value (pM))	126.91 ± 61.15	-5.070	25.903	-0.20	0.847

*Indicates statistically significant results. P-value associated with linear regression analysis. Participants with BMI>28 kg/m² excluded from regression analysis unless otherwise specified
^A No exclusion of participants with BMI>28 in this analysis

Table 5: Effects of theFunctional (Non-Null) GSTM1 Genotype on HIV Disease Progression and Oxidative Stress in Alcohol-Drinking Sub-Cohort.

Goto home»