| |
Chromium (N = 20) |
Placebo (N = 19) |
P-value
changea |
| Variable |
Baseline |
Week 8 |
Baseline |
Week 8 |
| HOMA – IRb (units) |
0.96 (1.35) |
1.25 (2.09) |
0.64 (3.24) |
0.64 (2.04) |
NSc |
| Glucose AUC |
5.77 ± 0.11 |
6.07 ± 0.13 |
5.78 ± 0.07 |
5.87 ± 0.15 |
NS |
| Triglycerides (mmol/L) |
1.68 ± 0.17 |
1.64 ± 0.17 |
1.65 ± 0.23 |
1.30 ± 0.21 |
NS |
| Total Cholesterol (mmol/L) |
4.18 ± 0.20 |
4.21 ± 0.18 |
4.38 ± 0.21 |
4.04 ± 0.18 |
0.013 |
| LDL Cholesterol (mmol/L) |
2.41 ± 0.18 |
2.61 ± 0.28 |
2.43 ± 0.21 |
2.24 ± 0.20 |
NS |
| HDL Cholesterol (mmol/L) |
1.01 ± 0.05 |
1.12 ± 0.06 |
1.20 ± 0.09 |
1.21 ± 0.09 |
0.043 |
| CD4 Count |
676 ± 78 |
762 ± 104 |
686 ± 60.67 |
674.5 ± 63.21 |
NS |
| CRP (mg/dL) |
2.9 ± 0.3 |
5.5 ± 0.5 |
3.2 ± 0.2 |
3.1 ± 0.2 |
NS |
| Systolic BP (mm/Hg) |
128 ± 2 |
130 ± 3 |
124.3 ± 3.29 |
124.3 ± 2.86 |
NS |
| Diastolic BP (mm/Hg) |
77 ± 2 |
74 ± 3 |
77.3 ± 2.03 |
74 ± 1.94 |
NS |
| BMI (kg/m2) |
28.2 ± 0.8 |
27.3 ± 0.7 |
26.8 ± 1.1 |
27.0 ± 0.83 |
NS |
| Limb Fat % |
45.9 ± 1.8 |
45.6 ± 2.4 |
49.2 ± 1.81 |
48.5 ± 7.84 |
NS |
| Trunk Fat % |
54.2 ± 1.8 |
52.7 ± 1.8 |
50.9 ± 1.81 |
50.7 ± 1.65 |
NS |
afrom an independent t –test comparing the change in the chromium group and the change in the placebo group
bHOMA – IR is represented as the median (range), this variable only
cfrom a Mann Whitney U test for this variable only
Glucose AUC is the area under the curve of the glucose x time curve for 0-180min following oral ingestion of 75g of glucose; CRP is C-reactive protein; limb and trunk fat %
are the proportion of fat present in limbs or trunk as a proportion of total body fat, expressed as a %. Data are expressed as mean ± SEM. NS is non-significant, i.e. P>0.05. |