Binding pocket # LTNP Fast progressor Odds Ratio (OR) LTNP vs. Fast progressor LTNP vs. Fast progressor
HLA-A   N N Uncorrected  p value Bonferroni’s corrected p value
62Q B 18 (69.23%) 8 (34.78%) 4.2187 0.0336 0.2881
HLA-B            
11S F* 2 (7.69%) 8 (34.78%) 0.1562 0.0463 0.0463
24A B 21 (80.77%) 11 (47.83%) 4.5818 0.0343 0.1344
24S B 4 (15.38%) 13 (56.52%) 0.1398 0.0066 0.0546
45E B 4 (15.38%) 13 (56.52%) 0.1398 0.0066 0.1165
45T B 20 (76.92%) 8 (34.78%) 6.25 0.0072 0.2921
62G A and B 10 (38.46%) 2 (8.7%) 6.5625 0.0370 0.351
65R A and B 11 (42.31%) 2 (8.7%) 7.7 0.0195 0.6277
66N B 11 (42.31%) 2 (8.7%) 7.7 0.0195 0.0195
67M B 11 (42.31%) 2 (8.7%) 7.7 0.0195 0.2429
70S B 11 (42.31%) 2 (8.7%) 7.7 0.0195 0.1775
74D F 4 (15.38%) 12 (52.17%) 0.1667 0.0149 0.0149
77N F 22 (84.61%) 11 (47.83%) 6 0.0149 0.085
80I F 21 (80.77%) 8 (34.78%) 7.875 0.0029 0.0353
81A F 22 (84.61%) 11 (47.83%) 6 0.0149 0.0149
82L External§ 23 (88.46%) 11 (47.83%) 8.3636 0.0056 0.0056
83R External§ 23 (88.46%) 11 (47.83%) 8.3636 0.0056 0.0056
94T F 13 (50%) 22 (91.3%) 0.0454 0.0013 0.0013
95L F 6 (23.08%) 13 (56.52%) 0.2307 0.0354 0.2244
97S F 5 (19.23%) 14 (60.87%) 0.153 0.0071 0.1783
HLA-DR            
26Y 4 2 (7.69%) 8 (34.78%) 2.380952381 0.0463 0.912684596
73A 4 26 (100%) 18 (78.26%) N.A. 0.0417 0.0417
73G 4 9 (34.62%) 16 (69.56%) 0.231617647 0.0311 0.0311
74R 4 2 (7.69%) 8 (34.78%) 0.15625 0.0463 0.372758417
77N 4 2 (7.69%) 8 (34.78%) 0.15625 0.0463 0.158747122
77T 4 26 (100%) 18 (78.26%) N.A. 0.0417 0.149950893
Table 2: HLA phenotypic analysis of binding pocket amino acid polymorphism significantly associated with the study groups.
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