Antigen Assay T cell subset Week 10* Week 40
All ART- ART+ All ART- ART+
Vacc-5q DTH high n.a. 76 % 63 % (8)** 89 % (9) 84 % 78 % (9) 90 % (10)
DTH low n.a. 67 % 63 % (8) 80 % (10) 74 % 67 % (9) 80 % (10)
Proliferation CD4 59 % 50 % (8) 67 % (9) 58 % 44 % (9) 70 % (10)
CD8 35 % 25 % (8) 44 % (9) 42 % 22 % (9) 60 % (10)
CD25 CD8 21 % 29 % (7) 14 % (7) 31 % 44 % (9) 20 % (10)
IFN-γ+ CD4 8 % 0 % (6) 22 % (9) 30 % 29 % (7) 30 % (10)
CD8 33 % 33 % (6) 33 % (9) 47 % 29 % (7) 60 % (10)
Nat-5q*** Proliferation CD8 24 % 38 % (8) 11 % (9) 33 % 33 % (9) 33 % (9)
CD25 CD8 38 % 67 % (6) 14 % (7) 33 % 44 % (9) 22 % (9)
p17 protein Proliferation CD8 19 % 29 % (7) 11 % (9) 24 % 29 % (7) 20 % (10)
CD25 CD8 0 % 0 % (5) 14 % (7) 50 % 56 % (9) 44 % (9)
p24 protein Proliferation CD8 38 % 57 % (7) 22 % (9) 69 % 71 % (7) 67 % (9)
CD25 CD8 33 % 40 % (5) 29 % (7) 61 % 78 % (9) 44 % (9)
Tat protein Proliferation CD8 0 % 0 % (7) 0 % (9) 19 % 14 % (7) 22 % (9)
CD25 CD8 18 % 25 % (4) 14 % (7) 34 % 56 % (9) 11 % (9)
*No differences between the ART- and ART+ groups (Fisher exact test)
**Frequency of responses relative to baseline (total n)
***Nat-5q are the native, unmodified peptides corresponding to the vaccine.
Table 2: Responses to various antigens relative to baseline.