| Study Period |
Site |
Criteria for failure |
N |
Median Duration of ART (months) |
ART Regimen (%) |
≥1 DRM
(%) |
NNRTI
(%) |
M184V
(%) |
TAM
(%) |
TAM ≥3
(%) |
K65R
(%) |
Ref |
| Aug 2011- Dec 2012 |
Rural clinics |
1 × VL >1000 |
89 |
39.6 |
d4T/3TC/EFV (72)
d4T/3TC/LPVr (14)
ABC/3TC/EFV (9)
Other (6) |
91.0 |
71.9 |
78.7 |
23.4 |
5.5 |
5.6 |
Pillay et al.
[47] |
| Aug 2008 to Jan 2010 |
Urban Hospital |
1 × VL >1000 |
41 |
28.6 |
d4T/3TC/EFV (61) d4T/3TC/LPVr (15)
AZT/3TC/NVP (7)
Other (10) |
85.4 |
78.0 |
70.7 |
58.5 |
39.0 |
7.3 |
Green et al.
[46] |
| 2009 |
Urban Clinic |
1 × VL >1000 |
1 |
~22 |
D4T/3TC/RTV
AZT/3TC/LPVr |
NA |
NA |
NA |
NA |
NA |
NA |
Murphy et al.
[45] |
ART, antiretroviral therapy; N, number of patients genotyped; DRM, drug resistance mutation; TAM, thymidine analogue mutation; VL, viral load; NR, Not reported; NA, Not
applicable; Ref, Reference |
