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Figure 2: A) SSAT activity in human primary astrocytes transduced to express HIV Tat. A one-way ANOVA with Tukey-Kramer test was used to compare the groups (n =3). The mean differential between SSAT activity in the astrocytes transduced with HIV-Tat as compared to untransduced or transduced with Adeno-null in pmol/mg protein/hr are 27.93 ± 2.71, 12.03 ± 1.36, 12.03 ± 1.60, respectively. B) Acetyl-CoA pools in primary astrocytes expressing HIV Tat. A one-way ANOVA with Tukey-Kramer test was used to compare the groups. As consequence of polyamine flux, the acetyl-CoA levels are decreased in astrocytes expressing HIV Tat as compared to empty plasmid controls.
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