Covariates No at risk No of OIs cases Crude Hazard Ratio (95% CI) Adjusted  Hazard Ratio       ( 95% CI) P value
HAART Status
HAART 
Pre-ART

232
232

21
156

0.06 (0.03, 0.09)
1

0.07 (0.03, 0.16)
1
<0.001*
Sex         
Male
Female

167
297

91
86

1.89 (1.41, 2.54)
1

2.19 (1.55, 3.11)
1
<0.001*
Marital status
Married
Single
Divorced
Widowed

245
58
81
80

90
13
43
31

1
2.42 (1.67, 3.51)
0.66 (0.37, 1.18)
1.18 (0.78, 1.78)

1
1.45 (0.95, 2.22)
0.86 (0.47, 1.56)
1.68 (1.08, 2.60)


0.083
0.618
0.022*
Age category
15-24
25-34
35-44
>=45

121
177
121
45

60
66
43
8

1
0.38 (0.27, 0.55 )
0.30 (0.20, 0.46)
0.15 (0.07, 0.31)

1
0.44 (0.29, 0.65)
0.27 (0.17, 0.43)
0.18 (0.08, 0.39)

<0.001*
<0.001*
<0.001*
Supportive care
Present
Absent

166
298

51
126

1
1.40 (1.01, 1.93)

1
1.36 (0.98,1.89)
0.069
 Prophylaxis B           
Yes
No

279
185

72
105

0.19 (0.13, 0.26)
1
   
Prophylaxis F          
Yes
No

193
271

86
91

1.33 (.99, 1.79)
1
   
WHO Stage B     
Stage I or II
Stage III or IV

389
75

164
13

1
0.29 (0.16, 0.50)
   
Functional Status F     
Working 
Ambulatory and Bedridden
436
28
165
12
1
3.33 (2.38, 4.66)
   
Address
Urban
Rural

365
99

121
56

1
1.79 (1.30, 2.47)

1
1.62 (1.15, 2.27)
0.005*
Substance use B
Yes
No

82
382

45
132

2.50 (1.78, 3.52)
1

2.11 (1.46, 3.06)
1
<0.001*
Substance use F
Yes
No

80
384

43
134

2.21 (1.56, 3.12)
1

2.15 (1.47, 3.13)
1
<0.001*
CD4 count B
<200cells/µl
200-349cells/µl
350-499cells/µl
>=500cells/µl

33
133
144
154

16
64
56
41

0.07 (.04, 0.14)
0.09 (0.05, 0.15)
1.04 (0.75, 1.45)
1

1.16 (0.39, 3.58)
0.86 (0.40, 1.84)
1.71 (1.19, 2.46)
1
0.792
0.694
0.004*
CD4 count F          
<200cells/µl
200-349cells/µl
350-499cells/µl
>=500cells/µl

33
133
144
154

16
64
56
41

3.15 (1.75, 5.68)
2.09 (1.40, 3.11)
1.69 (1.12, 2.53)
1

3.36 (1.86, 6.08)
1.71 (1.13, 2.59)
1.72 (1.14, 2.58)
1

<0.001*
0.011*
0.010*
F =follow up, B= baseline, *= P-value <0.05 is considered as statistically significant
Table 4: Bivariate and multivariate Cox proportional hazard analysis for Predictors of developing OIs among HIV infected patients in public Health facilities of Arba Minch town, 2014.
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