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| Figure 3: Our studies also showed and that nerve growth factor (NGF) counters Vpr’s effects by acting on TrkAR and p75ntr signaling. A) DRG neuronal cultures pre-treated with NGF or a p75 receptor antagonist were protected from the neurite-inhibiting effects of recombinant Vpr. B) p75 receptor antagonism blocks the Vpr-induced decrease in the neurite promoting protein pGSK3β. C) Vpr immediately causes an increase in intracellular calcium levels in DRG neurons which is inhibited by pretreatment with p75 receptor antagonism. |
