Characteristic (Men’s) Multicenter AIDS Cohort Study Women’s Interagency HIV Study
  n=121 n=63
Age, mean (SD) 53.1 (7.5) 49.1 (8.9)
Female, n (%) 0 (0) 63 (100)
Race, n (%)    
White 100 (82.6) 23 (36.5)
Black 21 (17.4) 40 (63.5)
Hispanic, n (%) 3 (2.5) 5 (7.9)
Completed high school, n (%) 114 (94.2) 47 (74.6)
Marital status, n (%)    
Never married -- 21 (33.3)
Married -- 22 (34.9)
Divorced or widowed -- 20 (31.8)
Alcohol consumption, n (%)    
None 69 (57.0) 38 (60.3)
1-2 drinks per week 22 (18.2) 16 (25.4)
>2 drinks per week 30 (24.8) 9 (14.3)
Clinical History    
Number of study visits attended, mean (SD) 35 (16.0) 26 (6.3)
Tobacco use, n (%)    
Never 26 (21.5) 12 (19.1)
Former 58 (47.9) 23 (36.5)
Current 37 (30.6) 28 (44.4)
Cumulative pack-years tobacco use, median (IQR) 8.2 (0-33.2) 3.0 (0.04-12.4)
Asthma diagnosis, n (%) 15 (12.4) 22 (34.9)
Bronchodilator use in previous 3 months, n (%) 12 (9.9) 11 (17.5)
Hepatitis C infection, n (%) 13 (10.7) 30 (47.6)
History of bacterial or Pneumocystis jirovecii pneumonia, n (%) 40 (33.1) 14 (22.2)
ART use since last visit, n (%) 104 (86.0) 51 (81.0)
Current CD4 (cells/µL), median (IQR) 575 (440-794) 426 (264-677)
Nadir CD4 (cells/µL), median (IQR) 269 (155-358) 159 (65-286)
Current HIV RNA level (copies/mL), median (IQR) <40 (40-40) 102 (48-727)
Recreational Drug Use    
Percentage of total visits reporting recent drug use, median % (IQR) 56 (18-87) 31 (3-75)
Any drug use since last visit, n (%) 59 (48.8) 25 (39.7)
Pulmonary Function    
Airflow obstruction    
Post-BD FEV1/FVC ratio <0.70, n (%) 16 (13.2) 7 (11.1)
Post-BD FEV1/FVC ratio, mean (SD) 0.78 (0.08) 0.78 (0.07)
Diffusion impairment    
DLCO % predicted <80%, n (%) 65 (53.7) 53 (84.1)
DLCO % predicted <60%, n (%) 16 (13.2) 23 (36.5)
DLCO % predicted, mean (SD) 79 (19.0) 65 (14.0)
Radiographic emphysema,b n (%) 64 (65.3) 9 (15.3)
Table 1: HIV: Human Immunodeficiency Virus; SD: Standard Deviation; IQR: Interquartile Range; ART: Antiretroviral Therapy; μL: Microliter; BD: Bronchodilator; FEV1: Forced Expiratory Volume in 1 second; FVC: Forced Vital Capacity; DLCO: Diffusing Capacity for Carbon Monoxide. a: Survey questions differ between MACS and WIHS. Unavailable data represented with “--“.b: CT data available for 98 men and 59 women. Radiographic emphysema defined as >1% of lung voxels <-950 Hounsfield units.