Date* INR (0.9-1.2) Total Bilirubin (0-23 µmol/L) AST (7-40 U/L) ALT (10-45 U/L) ALP (35-125 U/L) 01/10/2013 1.05 12 96 40 115 01/28/2013   106 159 76 73 02/13/2013 1.16 79 198 59 77 03/15/2013   45 132 39 115 03/27/2014 1.18   168 63 70 04/30/2013 1.47 121 136 64 69 05/15/2013 1.64 232 236 90 76 05/24/2013 1.86 365 366 130 77 06/04/2013 1.81 286 149 59 65 06/11/2013 2.16 170 91 17 55 06/22/2013 2.65 231 86 28 62 06/24/2013 4.05 306 140 40 52 06/25/2013 7.86 310 140 38 57 06/26/2013 3.25 268 1222 198 60

Table 2: Liver function test results over time for Patient B. *Patient B was on ARV therapy between January 9 and February 1, 2013 with: emtricitibine/tenofovir , darunavir and ritonavir. From April 19 until May 17th, 2013 the patient was on: 3TC, raltegravir, etravirine, darunavir and ritonavir.

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