Virus strains Inhibitory concentration (IC50a) M522 M532 Drug-Resistant Strains HIV-1RTMF 4.6 ± 1.4 8.3 ± 1.2 HIV-1IIIB A17 Variant 2.0 ± 1.3 6.9 ± 1.5 HIV-1L10R/M461/L63P/V82T/184V 11.1 ± 1.3 1.3 ± 0.7 Laboratory Strains HIV-1IIIB 20.4 ± 1.5 9.7 ± 1.4 HIV-1MN 16.7 ± 1.1 8.3 ± 1.1

Table 1: Antiviral activities of M522 and M532 against drug-resistant, laboratory strains of HIV-1 in H9 cells. aAnti-HIV activity (IC50), 50% inhibitory concentration or concentration of each inhibitor required to inhibit viral replication by 50 % and calculated as (µM) ± SD. Results were obtained from three independent experiments performed in duplicate.

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