The effect of ART on ART-naïve individual’s

		CD4+ T-cell count		Plasma HIV RNA
Time period	Number of ART naive who received ART^a	Mean before first ART, cells/µl	Mean change after 6 month ART, cells/µl	Mean before first ART, log	Mean change after 6 month ART, log
Monotherapy era (1987-1995)	47	266 (192;339)	26 (-28;81)	N/A^b	N/A^b
Early cART era (1996-2004)	66	275 (223;326)	107 (71;143)*	4,35 (4,12;4,59)	-2,19 (-2,51;1,87)*
Late cART era (2005-2012)	78	295 (223;367)	159 (129;189)*	4,67 (4,46;4,87)	-3,20 (-3,46;-2,93)*
Total	191

*Significant change (p<0.0001).
aHIV positive individuals who received ART for 6 months or more who have not received ART previously for more than 5 months. bPlasma HIV RNA measurements not done before 1996.

Table 3: The effect of ART on ART-naïve individual’s plasma HIV RNA and CD4+ T-cell count. 95% confidence interval in parentheses.

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