IFIG (Δ Gene Symbol) p value [day_0 to week_3] p value [day_0 to week_12] Δ ISG20 1,27E-01 1,58E-01 Δ APOBEC3G 2,17E-01 2,21E-01 Δ OAS1 3,10E-01 3,43E-01 Δ IRF7 3,56E-01 3,79E-01 Δ IFIT1 4,06E-01 4,23E-01 Δ ISG15 4,50E-01 4,81E-01 Δ G1P3 5,46E-01 5,93E-01 Δ OAS2 6,17E-01 6,64E-01 Δ MX2 6,19E-01 6,82E-01 Δ SP110 6,75E-01 6,95E-01 Δ LY6E 6,79E-01 6,99E-01 Δ STAT1 6,94E-01 7,12E-01 Δ MX1 7,19E-01 7,48E-01 Δ TRIM5 7,21E-01 7,97E-01 Δ IFIT3 7,43E-01 7,99E-01 Δ PLSCR1 7,71E-01 8,21E-01 Δ IFI44 7,75E-01 8,42E-01 Δ IFITM1 8,28E-01 8,67E-01 Δ APOBEC3A 8,37E-01 8,78E-01 Δ EIF2AK2 9,03E-01 9,36E-01 Δ IFI27 9,79E-01 9,92E-01

No significant association between IFIG induction and median HIV-VL declines/week from day_0 to week_3 could be found in 8 HIV mono-infected patients receiving pegylated interferon alpha (PegIFNα) therapy. Δ is the mathematical symbol for induction. Gene Symbols correspond to Entrez Gene IDs (http://www.ncbi.nlm.nih.gov/gene). Of note, HIV viremia was still detectable in all HIV monoinfected donors at week_12; thus, the only pursuable aim regarding the role of IFIG induction in determining therapy outcome was here confined to examining correlations between IFIG expression changes and median HIV-VL decline/week from day_0 to week_12. Of note, no significant correlations were found in this regard. No accounting for FDR was considered necessary in these contrast as results did not reach significance (i.e., P>0.05).

Table 1: Association between Interferon inducible genes (IFIG) induction and Human Immunodeficiency Virus viral load (HIV-VL) declines.

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