(Δ Gene Symbol)
p value
[day_0 to week_3]
p value
[day_0 to week_12]
Δ ISG20 1,27E-01 1,58E-01
Δ APOBEC3G 2,17E-01 2,21E-01
Δ OAS1 3,10E-01 3,43E-01
Δ IRF7 3,56E-01 3,79E-01
Δ IFIT1 4,06E-01 4,23E-01
Δ ISG15 4,50E-01 4,81E-01
Δ G1P3 5,46E-01 5,93E-01
Δ OAS2 6,17E-01 6,64E-01
Δ MX2 6,19E-01 6,82E-01
Δ SP110 6,75E-01 6,95E-01
Δ LY6E 6,79E-01 6,99E-01
Δ STAT1 6,94E-01 7,12E-01
Δ MX1 7,19E-01 7,48E-01
Δ TRIM5 7,21E-01 7,97E-01
Δ IFIT3 7,43E-01 7,99E-01
Δ PLSCR1 7,71E-01 8,21E-01
Δ IFI44 7,75E-01 8,42E-01
Δ IFITM1 8,28E-01 8,67E-01
Δ APOBEC3A 8,37E-01 8,78E-01
Δ EIF2AK2 9,03E-01 9,36E-01
Δ IFI27 9,79E-01 9,92E-01
No significant association between IFIG induction and median HIV-VL declines/week from day_0 to week_3 could be found in 8 HIV mono-infected patients receiving pegylated interferon alpha (PegIFN╬▒) therapy. Δ is the mathematical symbol for induction. Gene Symbols correspond to Entrez Gene IDs (http://www.ncbi.nlm.nih.gov/gene). Of note, HIV viremia was still detectable in all HIV monoinfected donors at week_12; thus, the only pursuable aim regarding the role of IFIG induction in determining therapy outcome was here confined to examining correlations between IFIG expression changes and median HIV-VL decline/week from day_0 to week_12. Of note, no significant correlations were found in this regard. No accounting for FDR was considered necessary in these contrast as results did not reach significance (i.e., P>0.05).
Table 1: Association between Interferon inducible genes (IFIG) induction and Human Immunodeficiency Virus viral load (HIV-VL) declines.
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