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| Figure 1: HIV-positive serum antibody and opsonophagocytic titers. HIV-positive volunteers were immunized with PPV23. Serum samples were obtained on days 0 and 30 post-immunization. Volunteers were classified according to CD4 count, <200 or >200 cells, and pre-vaccination HAART use. All samples were tested for PPS14 and PPS23F-specific IgG and IgM titers by ELISA expressed as μg/ ml (n=43) (A-D) and functional activity by OPA expressed as opsonophagocytic titer (PPS14 n=42, PPS23F n=39) (E-F). Data are mean ± standard error of the mean. *p<0.05, **p<0.01, ***p<0.001. |
