| Allergen |
Modification |
Effects |
Remarks |
Reference |
| Lep d 2 |
Deletion of 2 cysteine molecules |
Significantly reduced IgE affinity |
Disrupted allergen conformation |
[23] |
| Par j 1/ Par j 2 |
Substituted 3 critical amino acids |
Reduced IgE affinity, induction of IgG blocking antibodies, stimulate T cell proliferation |
Efficacy tested with a dimer of the mutants |
[26] |
| Ric c 1/ Ric c 3 |
Alteration of glutamic acid residues in epitope |
Significant reduce in ability to induce mast cell degranulation |
|
[3] |
| Pen a 1 |
Substituted 12 critical amino acids in 5 epitope regions |
Reduced mediators release in a humanized RBL assay |
Maximal release of mediators under high concentration of mutants |
[4] |
| Phl p 5 |
Single mimotope peptide of an IgE epitope |
Down-regulated inflammatory response, reduced Th2 cytokines |
No T cells involvement |
[31] |
