The symptoms and disorders sometimes believed to be caused by CMA are numerous, but almost none of them are pathognomonic of CMA [3]
Systemic: hypotension, shock
GI: colitis, irritable colon, flatulence, diarrhea, abdominal pains (colics), gengivitis, malabsorption; nausea, constipation, stomatitis, vomiting
Respiratory: extrinsic allergic alveolitis, recurrent respiratory infections, upper airway obstruction, recurrent pneumonia (Heiner syndrome), rhinitis, serous otitis, sinusitis, laryngeal edema. pulmonary hemosiderosis, chronic cough, bronchitis, wheezing, dyspnea, recurrent fever;
Cutaneous: alopecia, angioedema, herpetiform dermatitis, eczema, urticaria, purpura, erythematous macular rash
Hematologic: iron-deficiency anemia, thrombocytopenia, gross/occult bloody stools
Urinary: albuminuria, cystitis, enuresis, minimal lesion glomerulonephritis, nephrotic syndrome;
Central nervous: migraine, epilepsy, attention deficit hyperactivity disorder, restless legs syndrome, chronic fatigue syndrome, tension-fatigue syndrome
Ocular: keratitis, uveitis
Various: rheumatoid arthritis (seronegative), insulin-dependent diabetes mellitus, recurrent periostitis, SIDS (sudden infant death syndrome) etc.
Table 3: Clinical manifestations ascribed to CMA.
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