Figure 1: Brief summary of the mechanism of Treg cells to maintain immune tolerance during immunotherapy. Our results indicated that Th2 cells anergy and the relationship of immune tolerance during IT might be mediated by induction of CD4+ Treg cells and CD8+ Treg cells with anti-inflammatory cytokine that produced soluble CD14, IL-10, and TGF-β. CD8+CD25+ Tregs, but not CD4+CD25+ Tregs, directly induced allergen induced CD4+CD45ROhi+ cells apoptosis.
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