a) Elastic moduli (G’) values in kPa for wild type (wt) fibroblasts in NF, NF+MMP and Matrigel scaffolds at days 1, 6 and 14. NF and NF+MMP scaffolds are significantly stiffer than Matrigel at all time points. Decreased stiffness was observed in NF scaffolds at day 14. No changes in stiffness were observed in NF+MMP scaffolds.
b) Elastic moduli (G’) values in kPa for diabetic (db) fibroblasts in NF, NF+MMP and Matrigel scaffolds at days 1, 6 and 14. Again, NF and NF+MMP scaffolds are significantly stiffer than Matrigel at all time points. NF scaffolds exhibited a significant increase in stiffness at day 6 followed by a significant decrease at day 14. No changes in stiffness were observed in NF+MMP scaffolds. G’ (kPa) is reported at frequency of 0.1 Hz. * p<0.05 when compared to NF-based samples, + p<0.05 when compared to NF samples, ^ p<0.05 when compared to day 1 samples of same experimental group, $ p<0.05 when compared to day 6 samples of same experimental group.
