Organs and tissues Histological signs   Exposed Concentrations (mgL-1)                 A B C D     0 26 39 59 Brain Congestion of blood vessels  and - - - -   cerebellum cells         Gill Scattered gill and thickening - 1/2 1/2 1/2   filaments but no lesions         Liver Diffuse fatty degeneration of - 1/2 - -   hepatocytes         Intestine Necrosis of surface epithelium and - - - -   shortening of villi         Muscle/flesh Goblets cell hyperplasia and - - - -   muscle necrosis and calcification         ++: = Present and distinct with morphological changes of histological signs on the organ and tissues. 1/2 = Present but less marked (mild) than usual - = No lesion and morphological changes in organ and tissues.

Table 5: Histopathological Changes Observed in the Organs and Tissues of Clarias gariepinus juveniles exposed to Fresh root-bark cold water extracts of P. zeylanica after 1-week withdrawal from Chronic-sub lethal Exposure.

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