Organs and tissues Histological signs   Exposed Concentrations (mgL-1)
           
    A B C D
    0 26 39 59
Brain Congestion of blood vesselsĀ  and - - - -
  cerebellum cells        
Gill Scattered gill and thickening - 1/2 1/2 1/2
  filaments but no lesions        
Liver Diffuse fatty degeneration of - 1/2 - -
  hepatocytes        
Intestine Necrosis of surface epithelium and - - - -
  shortening of villi        
Muscle/flesh Goblets cell hyperplasia and - - - -
  muscle necrosis and calcification        
++: = Present and distinct with morphological changes of histological signs on the organ and tissues. 1/2 = Present but less marked (mild) than usual
- = No lesion and morphological changes in organ and tissues.
Table 5: Histopathological Changes Observed in the Organs and Tissues of Clarias gariepinus juveniles exposed to Fresh root-bark cold water extracts of P. zeylanica after 1-week withdrawal from Chronic-sub lethal Exposure.
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