Drug Zero order release model First order release model Higuchi release model Korsmeyer-Peppas model
  K0a r2b K1a r2b KHa r2b ka nc r2b
STP 0.21 0.52 0.027 0.83 6.63 0.46 0.21 0.11 0.65
HI443 0.28 0.75 0.030 0.94 6.68 0.90 0.07 0.26 0.97
a Rate constant: K0 inμg/min; K1 inmin-1, KH inμg/min1/2, k in min-1
b Square of correlation coefficient
c Exponent explaining the drug release mechanisms and classified as Fickian diffusion (n ≤0.5), case-II transport (n = 1), anomalous transport (0.5<n<1), and super case-II transport (n>1)
Table 3: Kinetics of in-vitro release profile of STP and HI443 from solid lipid nanoparticles (SLNs).