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| Figure 4: Representative MRM chromatograms of (a) blank plasma ultrafiltrate, (b) plasma ultrafiltrate sample spiked with flucloxacillin and cefazolin at 0.005 mg/L, (c) plasma ultrafiltrate sample spiked with flucloxacillin and cefazolin at 1.0 mg/L, (d) plasma ultrafiltrate sample from a patient after intravenous administration of cefazolin (cefazolin concentration = 0.48 mg/L) and (e) plasma ultrafiltrate sample from a patient after intravenous administration of flucloxacillin (flucloxacillin concentration = 0.64 mg/L). In all cases, except blank plasma, the internal standard butobarbitone concentration was 0.2 mg/mL. |
