QC (µg/mL) |
Mean measured concentrations (µg/mL) (n=5) |
RE (%) |
CV (%) |
Acceptance criteria |
Propofol |
0.005 |
0.0055 |
9.00 |
8.13 |
<20% |
1 |
0.920711.0485106.1178 |
3.45 |
4.14 |
<15% |
10 |
10.48 |
5.73 |
100 |
6.12 |
11.67 |
Non-conjugated metabolites |
0.005 |
0.0051 |
2.38 |
6.37 |
<20% |
0.5 |
0.44885.094350.6116 |
0.68 |
2.58 |
<15% |
5 |
1.89 |
6.75 |
50 |
1.22 |
2.85 |
|
QC- Quality control; RE- Relative error; CV- Coefficient of variation |
Table 5: Between-run accuracy and between-run precision data. QC means quality control, RE relative error and CV is the coefficient of variation (n =3). |