| Stock solution stability frozen at -80°C for 3 weeks |
| QC |
Mean (n=3) |
RE; % |
| Propofol |
Q+OH |
Propofol |
Q+OH |
Propofol |
Q+OH |
| 0.005 |
0.005 |
0.0051 |
0.0051 |
1.22 |
1.76 |
| 100 |
50 |
100.53 |
50.52 |
0.53 |
1.63 |
| Organic phase stability at 4°C for 1 week |
| QC |
Mean (n=3) |
RE; % |
| Propofol |
Q+OH |
Propofol |
Q+OH |
Propofol |
Q+OH |
| 0.005 |
0.005 |
0.0050 |
0.0050 |
0.96 |
0.37 |
| 100 |
50 |
101.01 |
50.11 |
1.01 |
0.22 |
|
| QC- Quality control; Q+OH – Non-conjugated metabolites; RE – relative error |
| Table 6: Results from stability studies of propofol and its non-conjugated metabolites (Q+OH) stock solutions and ethyl acetate/ chloroform organic phase. |
