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Figure 4: Representative MRM chromatograms of (a) blank bone sample obtained from a patient during TKA surgery, (b) supernatant of immersed bone tissue suspensions spiked with vancomycin at 10 mg/L, (c) bone sample obtained from a patient after intraosseous injection of vancomycin during TKA surgery (vancomycin concentration = 1.3 mg/L). |