Sample Concentrationspiked (mg/L) Concentration found (mg/L)(Mean ± SD) Bias(%) Imprecision CV (%)
Intra-day        
  LLOQ 0.050 0.049 ± 0.0040 -0.60 8.1
  QC1 1.00 0.92 ± 0.036 -8.19 3.9
  QC2 10.0 10.0 ± 0.32 0.17 3.2
  QC3 50.0 51.6 ± 1.24 3.27 2.4
Inter-day    
  LLOQ 0.050 0.052 ± 0.0046 4.00 8.8
  QC1 1.00 1.03 ± 0.054 2.85 5.2
  QC2 10.0 10.2 ± 0.26 1.51 2.6
  QC3 50.0 50.1 ± 1.71 0.20 3.4
Table 2: Intra- and inter-day assay variance of the determination of vancomycin in supernatant of immersed bone tissue suspension (n = 6).
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