Mixture Storage conditions Variation of pH (%) Remaining concentration (%)
Light T 7 days 15 days 7 days 15 days
1 L F -6.6 -6.6 99.33 ± 1.00 98.53 ± 0.15
2 L RT -9.3 -10.0 100.20 ± 0.70 99.40 ± 0.50
3 PL F -8.7 - 97.00 ± 2.00 -
4 PL RT -9.9 - 98.40 ± 1.30 -
5 L F -12.6 -13.4 99.45 ± 1.02 98.30 ± 1.50
6 L RT -1.9 -1.7 99.09 ± 0.19 97.50 ± 2.40
7 PL F -1.1 - 98.00 ± 0.40 -
8 PL RT -2.9 - 99.00 ± 0.60 -
9 L F -1.8 -1.9 98.64 ± 0.10 97.00 ± 2.00
10 L RT -0.9 -1.2 98.30 ± 0.60 97.57 ± 0.06
11 PL F +0.4 - 98.30 ± 0.30 -
12 PL RT -1.2 - 98.60 ± 0.30 -
R L F - - 96.80 ± 0.90 74.68 ± 1.00
T: Temperature; L: Exposition to ambient light; PL: Protection from light
F: Refrigerated (4.9 ± 1.5°C); RT: Room temperature (27.0 ± 0.9°C);
R: Reconstituted
Table 2: Variation of pH and remaining concentration of fosaprepitant in mixtures during storage
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