Mixture Zero-order kinetic First-order kinetic
K0 ·10-4
(mg·mL-1·h-1)
R2 T90
(days)
K1·10-4
(mg·mL-1·h-1)
R2 T90 (days)
1 - - 15* - - 15*
2 - - 15* - - 15*
3 1.38 ± 0.20 0.8298 18 2.30 ± 0.40 0.8297 19
4 - - 7* - - 7*
5 - - 15* - - 15*
6 - - 15* - - 15*
7 - - 7* - - 7*
8 - - 7* - - 7*
9 2.01 ± 0.25 0.7112 54 0.78 ± 0.11 0.7109 56
10 - - 15* - - 15*
11 5.10 ± 0.70 0.8304 20 2.10 ± 0.30 0.8298 21
12 3.30 ± 0.50 0.8250 13 7.99 ± 1.06 0.8210 13
R - - 12 - -  
R: Reconstituted
*Maximum experimental time at which remaining fosaprepitant concentration measured was ≥90%.
Table 3: Degradation constants and T90 values for mixtures assayed.