Mixture |
Zero-order kinetic |
First-order kinetic |
K0 ·10-4
(mg·mL-1·h-1) |
R2 |
T90
(days) |
K1·10-4
(mg·mL-1·h-1) |
R2 |
T90 (days) |
1 |
- |
- |
15* |
- |
- |
15* |
2 |
- |
- |
15* |
- |
- |
15* |
3 |
1.38 ± 0.20 |
0.8298 |
18 |
2.30 ± 0.40 |
0.8297 |
19 |
4 |
- |
- |
7* |
- |
- |
7* |
5 |
- |
- |
15* |
- |
- |
15* |
6 |
- |
- |
15* |
- |
- |
15* |
7 |
- |
- |
7* |
- |
- |
7* |
8 |
- |
- |
7* |
- |
- |
7* |
9 |
2.01 ± 0.25 |
0.7112 |
54 |
0.78 ± 0.11 |
0.7109 |
56 |
10 |
- |
- |
15* |
- |
- |
15* |
11 |
5.10 ± 0.70 |
0.8304 |
20 |
2.10 ± 0.30 |
0.8298 |
21 |
12 |
3.30 ± 0.50 |
0.8250 |
13 |
7.99 ± 1.06 |
0.8210 |
13 |
R |
- |
- |
12 |
- |
- |
|
|
R: Reconstituted
*Maximum experimental time at which remaining fosaprepitant concentration measured was ≥90%. |
Table 3: Degradation constants and T90 values for mixtures assayed. |