Class Case No AGE BAC (g/L) MOR M3G M6G M3G/M6G Relevant circumstances I 1 45 0.1 358 1710 285 6.00 First injection?! Family denies a history of drug dependence 2 22 n.p. 294 1148 317 3.62 led to the hospital; reported a double dose of heroin 3 45 n.p. 166 250 60 4.17 Found dead in a toilet with a syringe nearby 4 44 0.3 254 266 92 2.89 Found dead at home with a syringe in the arm 5 31 n.p. 371 633 196 3.23 Found dead in a toilet with a syringe in the arm 6 34 0.4 60 788 165 4.78 Found dead in his car; injection sites at autopsy 7 27 n.p. 231 188 42 4.48 uk 8 28 n.p. 139 788 130 6.06 uk 9 30 n.p. 266 833 225 3.70 uk 10 40 n.p. 153 457 85 5.38 uk II 11 39 0.7 187 427 92 4.64 Found dead at home with a syringe nearby 12 22 0.5 646 398 90 4.42 Found dead at home with suspected “brown-sugar” 13 39 0.7 649 2307 721 3.20 History of drug dependence; injection sites at autopsy 14 42 2.2 117 46 14 3.29 History of drug dependence; found dead at his home 15 35 1.3 152 322 88 3.66 Found dead in a toilet with a syringe nearby 16 32 1.0 156 97 50 1.94 Found dead with a syringe nearby III 17 35 0.5 108 474 63 7.52 In treatment for heroin dependence 18 24 0.2 334 569 185 3.08 Found in his bed; no signs of injection; white foam and blood at the mouth and at the nose 19 30 0.1 515 2138 821 2.60 Found in his bed; no signs of injection; white foam and blood at the mouth and at the nose 20 45 0.6 1349 11 10 1.10 Found dead in a street with a syringe nearby 21 43 0.5 145 394 82 4.80 Found dead with a syringe nearby   Mean 316.68 678.29 181.57 4.03     ± SD 289.21 646.04 213.25 1.47     Min 60 11 10 1.10     MAX 1349 2307 821 7.52

Table 1: Classification, age, gender and blood ethanol concentration of the twenty-one cases analyzed by LC/MS-MS (BAC=Blood Alcohol Concentration; n.p.: not present, i.e. <0.5 g/L; M: male; uk: unknown). Concentrations (ng/mL) of morphine (MOR), morphine-3-β-Dglucuronide (M3G), morphine-6-β-D-glucuronide (M6G) concentration ratio of the analytes (n.d.: not detected; /not calculated). Mean, Standard Deviation (± SD) and range (min, MAX) of each analyte and of the ratios of analytes concentrations.

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