Gout patients
Body Weight
Diuresis
pH
Creatinine concentration(µg/ml)
Allopurinol concentration(µg/ml)
Renal clearance ml/min/kg
Clearance ratio
kg
ml/mint/kg
Urine
Serum
Urine
Serum
Urine
Serum
creatinine
allopurinol
1
56
16.106
5.6
7.36
10.4
3.32
5.737
8.702
0.015
10.618
7.79
2
48.5
36.880
5.15
7.45
29.5
2.88
10.649
5.564
0.059
70.581
14.9
3
46
18.292
5.2
7.42
33.5
2.89
7.596
35.168
0.043
3.951
9.26
4
58
12.540
5.95
7.45
35.2
2.87
7.282
20.527
0.049
4.448
9.66
5
64
10.104
4.85
7.44
26.7
3.17
8.442
24.967
0.037
3.416
2.71
6
68
19.778
5.25
7.4
7.01
3.08
12.036
62.432
0.005
3.813
6.07
7
60
19.007
5.5
7.44
3.89
2.54
7.765
42.718
0.008
3.455
4.26
8
50
41.655
5
7.25
11.6
2.49
7.964
42.900
0.102
7.733
5.65
9
59
12.674
5.31
7.41
19.7
2.91
11.640
18.898
0.035
7.806
3.19
10
48
12.711
5.23
7.46
12.3
3.04
7.219
36.878
0.025
2.488
9.71
Mean
55.75
19.975
5.304
7.408
18.98
2.919
8.633
29.876
0.038
11.831
6.86
SEM
2.3413
3.391
0.0992
0.0199
3.6364
0.0815
0.661
5.525
0.009
6.583
11.93
Table 1:
Mean data of renal clearance of allopurinol and endogenous creatinine in ten female Gout patients after oral administration of allopurinol (300 mg).
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