| Type of cancer |
Non-comparative
studies |
Type of non-comparative study |
Total number of
patients in noncomparative
studies |
Single arm
trial |
Prospective
case series |
Retrospective case
series |
Case report |
| Anal [2-5] |
4 |
0 |
2 |
1 |
1 |
19 |
| Bile duct [6-17] |
12 |
4 |
1 |
7 |
0 |
181 |
| Bladder [23-29] |
7 |
5 |
0 |
2 |
0 |
190 |
| Brain [30-34] |
5 |
3 |
0 |
2 |
0 |
292 |
| Breast [36-40] |
5 |
3 |
0 |
2 |
0 |
48 |
| Cervical [44-49] |
6 |
5 |
0 |
1 |
0 |
327 |
| Esophageal - early [51-73] |
23 |
0 |
14 |
9 |
0 |
413 |
Esophageal – advanced/inoperable
[62,76-83] |
9 |
0 |
3 |
6 |
0 |
566 |
| Eye [84-94] |
11 |
1 |
1 |
6 |
3 |
97 |
| Gastrointestinal [96-100] |
5 |
3 |
1 |
1 |
0 |
96 |
| Head and neck – nasopharyngeal [102] |
1 |
0 |
0 |
0 |
1 |
1 |
Head and neck – oral and laryngeal
[103,104,261] |
3 |
1 |
0 |
3 |
0 |
326 |
| Head and neck – oral [108-116,262] |
10 |
3 |
1 |
6 |
0 |
393 |
| Head and neck – laryngeal [263,264] |
2 |
2 |
0 |
0 |
0 |
34 |
Head and neck – oral and pharyngeal
[118-120] |
3 |
0 |
0 |
3 |
0 |
27 |
| Head and neck [121-128,265,266] |
10 |
7 |
1 |
2 |
0 |
343 |
| Intraperitonealcarcinomatosis and
sarcomatosis [130,131] |
2 |
2 |
0 |
0 |
0 |
122 |
| Colorectal – metastatic (liver) [132,267] |
2 |
2 |
0 |
0 |
0 |
31 |
| Lung [142-159] |
18 |
4 |
2 |
10 |
2 |
1154 |
| Mesothelioma [162,163,268] |
3 |
3 |
0 |
0 |
0 |
104 |
| Ovarian [165] |
1 |
1 |
0 |
0 |
0 |
8 |
| Pancreatic [269] |
1 |
0 |
0 |
1 |
0 |
16 |
| Pituitary [167] |
1 |
1 |
0 |
0 |
0 |
12 |
| Prostate [168-173] |
6 |
5 |
0 |
1 |
0
|
111 |
| Sarcoma [174] |
1 |
1 |
0 |
0 |
0 |
10 |
| Skin – basal cell [191-213] |
23 |
1 |
14 |
7 |
1 |
1302 |
| Skin – Bowen’s [237,238] |
2 |
0 |
1 |
0 |
1 |
15 |
| Skin – multiple (non-melanoma) [214-
236] |
23 |
3 |
9 |
11 |
0 |
1887* |
Skin – cutaneous T-cell lymphoma
[243-249] |
7 |
1 |
0 |
3 |
3 |
22 |
| Skin – Kaposi’s sarcoma [241,242] |
2 |
|
|
1 |
1 |
26 |
| Skin – melanoma [239,240] |
2 |
0 |
0 |
2 |
0 |
63 |
Skin – Paget’s disease, extramammary
[4,220,222,250-256] |
10 |
1 |
2 |
4 |
3 |
52 |
| Vulval [259,260] |
2 |
1 |
1 |
0 |
0 |
31 |
| Total |
222 |
61 |
52 |
89 |
16 |
8319 |
*Number of patients not reported for one study (reported number of lesions instead)