Group |
Mean ± SEM age (years) |
Sex |
Mean ± SEM PMI (hr) |
Median Braak Score |
NC |
86.3 ± 1.4 |
N=15; 4M, 11W |
2.8 ± 0.2 |
I |
PCAD |
85.8 ± 1.7a |
N=14; 3M, 11W |
2.8 ± 0.2 |
Vc |
MCI |
91.0 ± 1.9a,b |
N=7; 2M, 5W |
2.6 ± 0.2 |
IVc |
LAD |
80.8 ± 1.4a |
N=15; 7M, 8W |
3.6 ± 0.4 |
VIc |
DC |
68.9 ± 4.8 |
N=12; 7M, 5W |
3.5 ± 0.4 |
IIc |
aP < 0.05 compared to DC
bP < 0.05 compared to LAD
cP ≤ 0.05 compared to NC
NC=Normal Control; MCI=Mild Cognitive Impairment; PCAD=Preclinical
Alzheimer’s Disease; LAD=Late-stage Alzheimer’s Disease; DC=Diseased
Control; PMI=Postmortem Interval. |