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| Figure 4: Time course evaluation of CXCR4 expression on K562 and KGla cells was performed by immunostaining and now cytometry after the cells were treated with Fu, AFA-W, or a mixture of both Fu and AFA-W. Treatment with Fu led to an immediate (5 min) and sustained (1 h) increase in CXCR4 expression on both cell types. Incubation of the cells with a mixture of Fu and AFA-W resulted in a significant reduction of CXCR4 expression on the KGIA, but not K562, cells, indicating a competition between Fu and the AFA-derived LSL on KGla cells. |
