Premenopausal   Postmenopausal  
Specification Controls (n=15) Patients (n=30) P Controls (n=10) Patients (n=20) P
Free E2 % 1.75±0.25 2.4±0.2 <0.00003 2.0 ±0.7 2.5±0.5 <0.005
SHBG (nmol/litre) 60.3±25.0 50.2±21.0 <0.001 60.9±18.9 45.1±9.1 <0.005
Free T3 (pg/ml) 6.9±0.5 5.1±0.7 <0.00015 6.4±2.1 4.9±1.5 <0.025
Free T4 (pg/dl) 1.2 ±0.27 0.9±0.2 <0.037 1.2±0.85 1.0±0.5 <0.05
TSH (µunits/ml) 1.08 ± 0.6 1.02±0.8 Not Significant 1.22±0..5 1.11±0.7 NS
TBG (µg/ml)Controls 20.7±3.2 19.0±2.8 Not significant 20.7±3 18.2±4.7 NS
Table 2: Free E2, SHBG, and thyroid functions in normal controls and patients with breast cancer.
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