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| Figure 1: IL-7 increased thymic and CNS metabolic rates. A. 4 female NHPs, 3yrs old were injected with 100 μg rIL-7/kg body weight s.c. four times with an 72hr interval. NHPs were 3 years of age and weighted between 4.4 and 5.2 kg. 2 NHPs received only diluents as a control. A PET-CT was performed a day prior to IL-7 application and 8 hours after the last IL-7 application. B. Mean SUV values for the two control monkeys (SMI9046 and 6120, top panel), who received only diluents and for four NHPs who received rIL-7. Values in black are from the PCT-CT prior to IL-7 injection and values in red are derived from the PET-CT after the fourth IL-7 application. C. PET-CT prior to and after IL-7 application in NHP 6026, increased thymic metabolism (red circle). D. Loss of CD4 and CD8 cell surface expression on circulating CD3+ T-cells after IL-7 injection. Cells were gated on CD3+ T-cells, CD16+/CD56+ NK-cells were excluded, followed by staining for CD4 and CD8 T-cell markers. The red quadrant represents CD3+, CD4-, CD8- T-cells. |
