Genotype WT-mice ERα-OE mice Sex Female Male Female Male Treatment Sham (n=12) MI (n=11) Sham (n=18) MI (n=12) Sham (n=14) MI (n=9) Sham (n=15) MI (n=9) BW [g] 22.03 ± 0.52 21.48 ± 0.54 28.17 ± 0.60 28.58 ± 0.78 22.33 ± 0.52 21.31 ± 0.53 27.64 ± 0.57 27.53 ± 0.75 TL [mm] 16.32 ± 0.13 16.35 ± 0.16 16.86 ± 0.09 16.81 ± 0.16 16.66 ± 0.11 16.39 ± 0.13 16.91 ± 0.10 16.54 ± 0.16 LVM [mg] 84.69 ± 2.97 90.94 ± 1.99 113.97 ± 2.10 121.10 ± 4.31 103.66§ ± 3.22 105.93 ± 4.07 134.98§ ± 5.91 130.90 ± 4.27 LVM/TL [mg/mm] 5.19 ± 0.17 5.57 ± 0.14 6.76 ± 0.13 7.20 ± 0.24 6.23§ ± 0.20 6.46 ± 0.24 7.98§ ± 0.34 7.90 ± 0.23 LVW [mm] 0.63 ± 0.02 0.57* ± 0.01 0.71 ± 0.01 0.62* ± 0.01 0.64 ± 0.01 0.62 ± 0.02 0.73 ± 0.01 0.65* ± 0.02 LVVol,d [μl] 40.90 ± 1.81 67.43* ± 6.64 52.71 ± 2.14 95.77* ± 8.95 59.75§ ± 3.25 74.64 ± 4.76 63.56§ ± 3.52 94.53* ± 5.32 LVVol,s [μl] 14.01 ± 1.26 47.51* ± 6.14 19.98 ± 1,18 67.74* ± 10.72 31.23§ ± 3.24 50.50 ± 6.30 31.63§ ± 2.93 69.40* ± 5.55 HR [bpm] 480.3 ± 14.80 525.5 ± 12.36 495.8 ± 10.12 515.8 ± 12.65 472.5 ± 11.66 459.6 ± 20.26 462.5 ± 20.21 522.3 ± 38.54 LVSV [μl] 26.89 ± 1.31 19.92 ± 1.28 32.73 ± 1.28 28.03 ± 2.35 28.52 ± 1.65 24.14 ± 2.53 31.45 ± 1.90 24.65 ± 3.03 LVCO [ml/min] 13.11 ± 0.86 10.41 ± 0.64 16.16 ± 0.71 14.72 ± 1.39 13.49 ± 1.01 10.25 ± 1.19 15.33 ± 1.13 12.42 ± 1.32 Infarctsize (%) ------- 35.23 ± 3.38 ------- 33.46 ± 3.92 ------- 29.18 ± 3.28 ------- 28.89 ± 3.61 Data are means ± SEM. MI: Myocardial Infarction; Sham: sham operation; F: female; M: male; n: number of animals; BW: body weight; TL: tibia length; HW: heart weight; LVM: left ventricular (LV) mass; LVW: LV wall thickness; LVVol,d: LV diastolic volume; LVVol,s: LV systolic volume; HR: heart rate; LVSV: LV stroke volume; LVCO: LV cardiac output. All data are shown as Mean ± SEM. *p<0.05 MI vs. sham, §p<0.05 ERα-OE vs. WT.

Table 1: Morphological and echocardiographic parameters 2 weeks after sham and MI surgery in female and male WT- and ERα-OE mice.

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