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| Figure 5: BMSCs accelerated wound healing after whole-body ionizing irradiation combined with skin wound (CI). B6D2F1/J mice were exposed to &gamma-radiation followed by 15% TBSA skinwound trauma. BMSCs (approximately 3 × 106 cells per mouse)were injected via tail vein 24 h after CI. N=10–11 per group,repeated once. a. 9.25 Gy. Wound was fully closed by day 21 after CI. *P<0.05 vs. CI+DMEM. b. 9.75 Gy. Wound was not fully healed by day 30 after CI. c. Representatives of wound closure on the back of mice. Mice were exposed to 9.25 Gy followed by 15% TBSA skinwound trauma. BMSCs (approximately 3 × 106 cells per mouse)were injected via tail vein 24 h after CI. *p<0.05 vs. respective wound areas at day 1; ^p<0.05 vs. CI+DMEM. CI: radiation + wound; DMEM: Dulbecco’s Modified Eagle’s Medium |
