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| Figure 1: Neuronal activity (as indexed by c-Fos positive neuronal numbers) in entorhinal cortex and associated cognitive performance in very old Tg and NT mice given two-months of EMF treatment. (A) Photomicrographs of c-Fos positive neurons in entorhinal cortex from representative Tg and NT mice given EMF treatment or sham/control treatment. Note the greater number of c-Fos positive neurons in both Tg and NT mice given EMF treatment vs. controls. Bar = 50μm. (B) Number of c-Fos positive neurons in entorhinal cortex of NT mice given EMF or sham treatment. *p < 0.01 (C) c-Fos positive neuronal numbers in Tg mice given EMF or sham treatment. †p = 0.07 (D) Number of c-Fos positive neurons in entorhinal cortex for combined NT and Tg groups given EMF or sham treatment. *p < 0.02 (E) General mneumonic memory, as indexed by Y-maze percent alternations, in EMF-treated and control mice irrespective of genotype. Data are present in reference to the mean for the control group standardized to 100%. *p < 0.05 |
