Brain Region

 ChAT activity

 ChAT mRNA

 ChAT protein

 NOS activity

 NOS protein

 NOS mRNA

 Frontal Cortex

 ↓(*)

 Total:↔
M-ChAT:↔

 ND

 

nNOS: 
eNOS:
ND
iNOS:↔

 nNOS:↔
eNOS:↓(*)
iNOS:ND

Hippocampus ↓(+) Total:↔
M-ChAT:↔
variable nNOS: 
eNOS:
ND
iNOS:↔
nNOS:↔
eNOS:↓(*)
iNOS:ND
Nucleus basalis of Meynert Total:↔
M-ChAT: ↓
variable nNOS: 
eNOS:
ND
iNOS:↔
nNOS:↔
eNOS:↓(*)
iNOS:ND
Caudate Total:↔
M-ChAT:↔
nNOS: 
eNOS:
ND
iNOS:↔
nNOS:↔
eNOS:↓(*)
iNOS:ND
ChAT, choline acetyltransferase; NOS, nitric oxide synthase; n, neuronal; e, endothelial; I, inducible; ↓, decrease; (*), statistically significant difference; (+), difference approached statistical significance; ↔, no change compared to control tissue; ND, not detected in most/all samples
Table 3: Summary of changes in ChAT and NOS expression in AD.
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