| AD versus normal aging |
Unit |
Odds Ratio (95%CI) |
Significance |
| Non-PVC model |
| gender |
1 |
2.395 (0.664 - 8.639) |
0.1822 |
| education |
3.2426 |
0.561 (0.295 - 1.068) |
0.0784 |
| age |
6.0469 |
0.203 (0.079 - 0.523) |
0.001 |
| frontal pole |
131.3 |
0.621 (0.321 - 1.201) |
0.1571 |
| fusiform |
1171.9 |
0.483 (0.229 - 1.019) |
0.0561 |
| precuneus |
1003.1 |
0.132 (0.044 - 0.393) |
0.0003 |
| rostral anterior cingulate |
276.6 |
2.040 (1.002 - 4.156) |
0.0495 |
| isthmus of the cingulate |
272.3 |
2.725 (1.090 - 6.808) |
0.0319 |
| insula |
660.4 |
2.997 (1.271 - 7.067) |
0.0121 |
| parahippocampal gyrus |
305.3 |
0.441 (0.214 - 0.909) |
0.0265 |
| superior parietal |
1458.7 |
3.218 (1.245 - 8.318) |
0.0159 |
| hippocampus |
621.4 |
0.012 (0.002 - 0.067) |
<0.0001 |
| Cortical thickness + subcortical volume residuals |
| gender |
1 |
1.408 (0.575 - 3.45) |
0.4541 |
| education |
3.2426 |
0.526 (0.344 - 0.802) |
0.0029 |
| age |
6.0469 |
0.703 (0.470 - 1.051) |
0.0855 |
| entorhinal |
246.9 |
0.597 (0.391 - 0.912) |
0.0171 |
| inferior temporal |
1297.9 |
0.595 (0.368 - 0.961) |
0.0339 |
| paracentral gyrus |
328.2 |
2.671 (1.640 - 4.351) |
<0.0001 |
| parahippocampal gyrus |
183.3 |
0.505 (0.307 - 0.833) |
0.0074 |
| amygdala |
23.6388 |
0.322 (0.195 - 0.530) |
<0.0001 |
| thalamus |
52.2657 |
0.612 (0.411 - 0.911) |
0.0156 |
| Gray matter mask |
| gender |
1 |
1.072 (0.450 - 2.551) |
0.8757 |
| education |
3.2507 |
0.574 (0.379 - 0.869) |
0.0087 |
| age |
5.9331 |
1.051 (0.705 - 1.567) |
0.8079 |
| entorhinal |
1508.9 |
0.103 (0.033 - 0.325) |
0.0001 |
| isthmus of the cingulate |
2183.6 |
0.423 (0.120 - 1.495) |
0.1818 |
| middle temporal |
1686 |
0.231 (0.106 - 0.501) |
0.0002 |
| paracentral gyrus |
2075.2 |
2.471 (1.020 - 5.987) |
0.0452 |
| parahippocampal gyrus |
1576.2 |
4.218 (1.220 - 14.579) |
0.0229 |
| postcentral gyrus |
1575.6 |
3.685 (1.463 - 9.279) |
0.0056 |
| precuneus |
2083.1 |
0.333 (0.102 - 1.087) |
0.0684 |
| temporal pole |
1264.5 |
3.130 (1.132 - 8.655) |
0.0279 |
The top model shows the non-pvc model (c = 0.972), followed by the cortical thickness + subcortical volume residuals (c = 0.864), and the GMM on the bottom (c = 0.879). |
