Authors Year Reference Methods Number of subjects Al detection
AD control
Terry and Pena 1965 [13] EDX 1 - -
Perl and Brody 1980 [129] EDX 3 3 +
Masters et al. 1985 [130] EDX 6 - +
Kobayashi et al. 1987 [131] WDX 1 - -
Jacobs et al. 1989 [113] EDX 7 4 -
Moretz et al. 1990 [132] EDX 3 - -
Chafi et al. 1991 [133] WDX, SIMS 7 - -
Sparkman 1993 [134] EDX N/A N/A -
Lovell et al. 1993 [104] LMMS 7 5 - (+ in neuron)
Kasa et al. 1995 [135] solachrone azurine 10 5 ±
Bouras et al. 1997 [106] LMMS 4 3 +
Reusche 1997 [136] LMMS 1 (DAE) - - (+ in DAE)
Makjanic et al. 1998 [117] STIM  6 4 -
Murayama et al. 1999 [137] Chelating autoclave 5 - +
EDX: energy-dispersive X-ray spectroscopy; WDX: wavelength-dispersive X-ray microanalysis; SIMS: secondary ion mass spectrometry; LMMS: laser microprobe mass spectrometry; STIM: scanning transmission ion microscopy.
Table 5: Detection of Al in neurofibrillary tangles of AD brain tissues.
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